Department of Clinical Oncology and Radiotherapy, Charles University Hospital and Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czech Republic.
Strahlenther Onkol. 2010 Aug;186(8):452-7. doi: 10.1007/s00066-010-2132-3. Epub 2010 Jul 29.
Standard treatment of glioblastoma multiforme consists of postoperative radiochemotherapy with temozolomide, followed by a 6-month chemotherapy. Serious hematologic complications are rarely reported.
The authors present the case of a 61-year-old female patient with glioblastoma multiforme treated with external-beam radiation therapy and concomitant temozolomide. After completion of treatment, the patient developed symptoms of serious aplastic anemia that eventually led to death due to prolonged neutro- and thrombocytopenia followed by infectious complications.
Lethal complications following temozolomide are, per se, extremely rare, however, a total of four other cases of aplastic anemia have been reported in the literature so far.
多形性胶质母细胞瘤的标准治疗包括术后替莫唑胺放化疗，随后进行 6 个月的化疗。严重的血液学并发症很少见。
作者报告了一例多形性胶质母细胞瘤患者的病例，该患者接受了外照射放疗和替莫唑胺联合治疗。治疗完成后，患者出现严重再生障碍性贫血症状，最终因中性粒细胞和血小板减少持续时间延长并继发感染并发症而死亡。
替莫唑胺治疗后的致死性并发症本身极为罕见，但迄今为止，文献中总共报告了其他 4 例再生障碍性贫血病例。
