Gildenberg P L, Pettigrew L C, Merrell R, Butler I, Conklin R, Katz J, DeFrance J
University of Texas Medical School, Houston.
Stereotact Funct Neurosurg. 1990;54-55:268-71. doi: 10.1159/000100221.
Stereotactic techniques were used to transplant adrenal medullary tissue to the head of the right caudate nucleus in 12 patients with Parkinson's disease. No significant lasting complications were seen. All patients had an initial improvement. 11 of the 12 patients remain improved over their preoperative condition after 6-18 months, 3 with good results and 9 with only modest improvement. At 6 months, the mean Schwab and England score had improved from 59.2 +/- 18.8 preoperatively to 75.8 +/- 15.1 (p less than or equal to 0.01) and the mean Hoehn and Yahr scale had improved from 3.42 +/- 0.90 to 2.92 +/- 0.63 (p less than or equal to 0.01).
采用立体定向技术将肾上腺髓质组织移植到12例帕金森病患者的右侧尾状核头部。未观察到明显的长期并发症。所有患者最初均有改善。12例患者中有11例在6 - 18个月后仍比术前状况有所改善，其中3例效果良好，9例仅有轻微改善。在6个月时，施瓦布和英格兰评分均值从术前的59.2±18.8提高到75.8±15.1（p≤0.01），霍恩和雅尔分级均值从3.42±0.90提高到2.92±0.63（p≤0.01）。
