Department of Food & Nutrition, Hanyang University, Seoul, South Korea.
Int J Vitam Nutr Res. 2010 Apr;80(2):97-106. doi: 10.1024/0300-9831/a000010.
Soy isoflavones have been reported to decrease the risk of atherosclerosis in postmenopausal women. However, the effects of dietary consumption of soybean have not been explored. In this study, we evaluated the effects of consuming yellow soybeans, black soybeans (Glycine max), or sword beans (Canavalia gladiate) on lipid and oxidative stress levels in an ovariectomized rat model. Forty-seven nine-week-old female rats were ovariectomized, randomly divided into four groups, and fed one of the following diets for 10 weeks: a diet supplemented with casein (NC, n = 12), a diet supplemented with yellow soybean (YS, n = 12), a diet supplemented with black soybean (BS, n = 12), or a diet supplemented with sword bean (SB, n = 11). Plasma triglyceride (TG) levels in the BS and SB groups were significantly lower than that in the NC group. Notably, the BS group had significantly lower plasma total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) levels than the other groups. Hepatic total lipid levels were significantly lower in the YS and SB groups, and cholesterol levels were significantly lower in the SB group than in the NC group. Superoxide dismutase (SOD) and catalase (CAT) activities were significantly higher in the groups fed beans compared to the NC group. Hepatic thiobarbituric acid reactive substances (TBARS) levels were also significantly lower in the BS and SB groups than the NC group. In conclusion, our results suggest that consumption of various types of beans may inhibit oxidative stress in postmenopausal women by increasing antioxidant activity and improving lipid profiles. Notably, intake of black soybean resulted in the greatest improvement in risk factors associated with cardiovascular disease.
大豆异黄酮已被报道可降低绝经后妇女患动脉粥样硬化的风险。然而，食用大豆的饮食作用尚未得到探索。在这项研究中，我们评估了食用黄大豆、黑大豆（Glycine max）或刀豆（Canavalia gladiate）对去卵巢大鼠模型脂质和氧化应激水平的影响。47 只 9 周龄雌性大鼠去卵巢后，随机分为四组，分别喂食以下四种饮食 10 周：酪蛋白补充饮食（NC 组，n = 12）、黄大豆补充饮食（YS 组，n = 12）、黑大豆补充饮食（BS 组，n = 12）或刀豆补充饮食（SB 组，n = 11）。BS 和 SB 组的血浆甘油三酯（TG）水平明显低于 NC 组。值得注意的是，BS 组的血浆总胆固醇（TC）和低密度脂蛋白胆固醇（LDL-C）水平明显低于其他组。YS 和 SB 组的肝总脂质水平明显较低，SB 组的胆固醇水平明显低于 NC 组。与 NC 组相比，喂食豆类的各组的超氧化物歧化酶（SOD）和过氧化氢酶（CAT）活性明显更高。BS 和 SB 组的肝丙二醛（TBARS）水平也明显低于 NC 组。总之，我们的结果表明，食用各种豆类可能通过增加抗氧化活性和改善脂质谱来抑制绝经后妇女的氧化应激。值得注意的是，摄入黑大豆可最大程度地改善与心血管疾病相关的风险因素。
