Kekulé Institute for Organic Chemistry and Biochemistry, Bonn University, Gerhard-Domagk-Strasse 1, 53121 Bonn, Germany.
Org Lett. 2010 Oct 1;12(19):4288-91. doi: 10.1021/ol101698a.
Multiply fluorine-substituted iodo anisoles are efficiently coupled in an Ullmann-type reaction to provide the corresponding bisanisoles. The coupling is selective and even tolerates bromo moieties. Subsequent deprotection of hydroxy groups gives access to highly fluorinated biphenols.
多氟碘代苯甲醚在乌尔曼型反应中高效偶联，得到相应的双苯甲醚。该偶联反应具有选择性，甚至可以容忍溴取代基。随后脱除羟基保护基，可得到高氟化联苯酚。
