Department of Obstetrics and Gynecology, Aarhus University Hospital, Skejby, Aarhus, Denmark.
Acta Obstet Gynecol Scand. 2010 Sep;89(9):1118-25. doi: 10.3109/00016349.2010.505639.
Pregnancy-associated plasma protein-A (PAPP-A) is highly efficient as a serum marker in first-trimester screening for chromosomal abnormalities. Furthermore, there is increasing evidence that low levels of PAPP-A in the first trimester are associated with adverse pregnancy outcomes such as preterm delivery, intrauterine growth retardation, preeclampsia, and stillbirth. PAPP-A is a glycoprotein, produced in the placenta, and it is present in the maternal circulation in increasing concentrations during pregnancy. By means of its proteolytic activity, PAPP-A functions as a regulatory protein in the insulin-like growth factor system, known to be important for placental formation and regulation of fetal growth. This overview describes aspects of biochemistry, synthesis, and biological functions of PAPP-A, with a focus on information of importance to clinicians. The clinical applications of PAPP-A are summarized, and new insights regarding the analyses of PAPP-A discussed.
妊娠相关血浆蛋白 A（PAPP-A）在早孕期筛查染色体异常方面是一种非常有效的血清标志物。此外，越来越多的证据表明，早孕期 PAPP-A 水平低与不良妊娠结局相关，如早产、宫内生长受限、子痫前期和死胎。PAPP-A 是一种糖蛋白，在胎盘内产生，在怀孕期间，它存在于母血循环中，并逐渐增加。通过其蛋白水解活性，PAPP-A 在胰岛素样生长因子系统中发挥调节蛋白的作用，该系统对于胎盘形成和胎儿生长的调节非常重要。这篇综述描述了 PAPP-A 的生化、合成和生物学功能的各个方面，重点介绍了对临床医生重要的信息。总结了 PAPP-A 的临床应用，并讨论了对 PAPP-A 分析的新见解。
