Dermatology Clinic, Bolu Izzet Baysal State Hospital, Bolu, Turkey.
J Dermatolog Treat. 2011 Aug;22(4):215-20. doi: 10.3109/09546631003675450. Epub 2010 Aug 30.
Quality of life measures are increasingly being used in the evaluation of oral disease outcome. To date, there has been less focus on oral health-related quality of life (OHR-QoL) measures for oral diseases in dermatologic literature.
To test whether patients with recurrent aphthous stomatitis (RAS) report a lower OHR-QoL than the general population and to evaluate therapeutic regimens for RAS by using OHR-QoL measures.
A total of 128 patients and 40 controls were enrolled. A questionnaire entitled the 14-item oral health impact profile (OHIP-14) was completed. Forty-three (33%) of the patients were followed-up and completed the OHIP-14 following treatment.
The median total score of patients on colchicine before treatment was 21. Following use of colchicine, the total score was 10. There was a significant difference concerning the impact of oral health following use of oral colchicine. However, no reduction of OHIP-14 scores was observed in the topical treatment group.
When the influence of one of the most common oral diseases such as RAS on OHR-QoL was taken into consideration, OHR-QoL provides an additional dimension that may help to improve the impact of a disease on an individual's life. In relation to this, colchicine seems to be one of the most effective management strategies used in RAS.
生活质量评估在口腔疾病的疗效评估中应用日益广泛。迄今为止，皮肤科文献对口腔疾病相关生活质量（OHR-QoL）评估的关注度较低。
检测复发性阿弗他溃疡（RAS）患者的 OHR-QoL 是否低于一般人群，并通过 OHR-QoL 评估 RAS 的治疗方案。
共纳入 128 例患者和 40 例对照者。患者填写了包含 14 个项目的口腔健康影响量表（OHIP-14）。43 例（33%）患者接受治疗后完成了 OHIP-14 量表。
在使用秋水仙碱治疗前，患者的 OHIP-14 总分中位数为 21 分，使用秋水仙碱治疗后为 10 分。使用秋水仙碱对口腔健康的影响有显著差异。然而，局部治疗组的 OHIP-14 评分没有降低。
当考虑最常见的口腔疾病之一（如 RAS）对 OHR-QoL 的影响时，OHR-QoL 提供了一个额外的维度，可以帮助改善疾病对个人生活的影响。在这方面，秋水仙碱似乎是治疗 RAS 最有效的管理策略之一。
