鼠尾草（Salvizan 凝胶）与曲安奈德治疗复发性阿弗他口腔溃疡的效果比较：一项双盲随机临床试验。
The effect of sage (Salvizan gel) compared to triamcinolone acetonide on the treatment of recurrent aphthous stomatitis: a double-blinded randomized clinical trial.
机构信息
Department of Oral and Maxillofacial Medicine, Dental Research Center, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
Student Research Committee, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
BMC Oral Health. 2023 Mar 18;23(1):157. doi: 10.1186/s12903-023-02861-y.
BACKGROUND
Recurrent Aphthous Stomatitis (RAS) is one of the most common lesions of the oral mucosa. Herbal medicine can be used for the treatment of this disease. The present study aimed to compare the effects of topical application of Sage (Salvizan) and triamcinolone acetonide gels on RAS.
METHODS
This double-blind clinical study recruited sixty patients with minor aphthous ulcers. Half of the patients were treated with Salvizan gel, and the other half were treated with oral triamcinolone acetonide gel. The effect of Salvizan topical gel was evaluated and compared with that of oral triamcinolone acetonide gel. Factors such as Pain recovery time, wound healing time, and pain level was evaluated. Data were analyzed by SPSS version 22 using independent t-test, paired t-test, repeated measures ANOVA, and survival analysis, including Kaplan-Meier and Cox regression.
RESULTS
The mean duration of pain recovery was 1.5 days for Salvizan and 2.5 days for triamcinolone acetonide (p < 0.001). Moreover, the duration of wound healing was 3.3 days for Salvizan and 6 days for triamcinolone acetonide (p < 0.001). Patients' satisfaction from factors such as taste and smell had no significant difference between the two groups.
CONCLUSION
The results of this study showed that Salvizan gel is very effective in the treatment of RAS. It was significantly better than triamcinolone acetonide in the pain recovery and wound healing. These promising results favor herbal treatments and show that they can be used more commonly for treating diseases such as RAS.
TRIAL REGISTRATION
This study was approved by the ethics committee of Isfahan University of Medical Sciences (IR.MUI.
RESEARCH
REC.1399.834) on 17/03/2021. It was also registered in the Iranian Registry of Clinical Trials (IRCT20100202003251N7).
背景
复发性阿弗他口炎（RAS）是口腔黏膜最常见的病变之一。草药可用于治疗这种疾病。本研究旨在比较局部应用鼠尾草（Salvizan）和曲安奈德凝胶治疗 RAS 的效果。
方法
这项双盲临床研究招募了 60 名患有小阿弗他溃疡的患者。一半的患者用 Salvizan 凝胶治疗，另一半用口服曲安奈德凝胶治疗。评估并比较 Salvizan 局部凝胶的效果。评估了疼痛恢复时间、伤口愈合时间和疼痛水平等因素。数据采用 SPSS 版本 22 通过独立 t 检验、配对 t 检验、重复测量方差分析和生存分析（包括 Kaplan-Meier 和 Cox 回归）进行分析。
结果
Salvizan 组疼痛恢复时间的平均值为 1.5 天，曲安奈德组为 2.5 天（p<0.001）。此外，Salvizan 组的伤口愈合时间为 3.3 天，曲安奈德组为 6 天（p<0.001）。两组患者在味觉和嗅觉等因素的满意度方面无显著差异。
结论
本研究结果表明，Salvizan 凝胶治疗 RAS 非常有效。在疼痛恢复和伤口愈合方面明显优于曲安奈德。这些有希望的结果支持草药治疗，并表明它们可以更常用于治疗 RAS 等疾病。
试验注册
本研究于 2021 年 3 月 17 日获得伊斯法罕医科大学伦理委员会（IR.MUI.REC.1399.834）的批准。它还在伊朗临床试验注册中心（IRCT20100202003251N7）注册。
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