梗阻性肾病中的氧化应激。
Oxidative stress in obstructive nephropathy.
机构信息
Department of Pathology, University Medical Center, Utrecht, The Netherlands.
出版信息
Int J Exp Pathol. 2011 Jun;92(3):202-10. doi: 10.1111/j.1365-2613.2010.00730.x. Epub 2010 Aug 27.
Abstract
Unilateral ureteric obstruction (UUO) is one of the most commonly applied rodent models to study the pathophysiology of renal fibrosis. This model reflects important aspects of inflammation and fibrosis that are prominent in human kidney diseases. In this review, we present an overview of the factors contributing to the pathophysiology of UUO, highlighting the role of oxidative stress.
摘要
单侧输尿管梗阻 (UUO) 是研究肾脏纤维化病理生理学最常用的啮齿动物模型之一。该模型反映了人类肾脏疾病中突出的炎症和纤维化的重要方面。在这篇综述中，我们介绍了导致 UUO 病理生理学的因素概述，强调了氧化应激的作用。
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Hypertension. 2010 Feb;55(2):468-73. doi: 10.1161/HYPERTENSIONAHA.109.145714. Epub 2009 Dec 28.
2
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J Am Soc Nephrol. 2010 Jan;21(1):93-102. doi: 10.1681/ASN.2009020146. Epub 2009 Nov 19.
3
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7
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