Department of Food and Nutrition, Inha University, Incheon, Korea.
J Biomed Sci. 2010 Aug 24;17 Suppl 1(Suppl 1):S39. doi: 10.1186/1423-0127-17-S1-S39.
Nelumbo nucifera, known as sacred lotus, is a well-known medicinal plant and this lotus root is commonly used as food compared to different parts of this plant. This study was conducted to investigate the antioxidant and hepatic protective effects of lotus root hot water extract with taurine supplementation in high fat diet-induced obese rats.
Thirty-two male Sprague-Dawley rats (4-week-old) were randomly divided into four groups (n=8) for 6 weeks (normal diet, N group; high fat diet, HF group; high fat diet + lotus root hot water extract, HFR group; high fat diet + lotus root hot water extract + taurine, HFRT group). Lotus root hot water extract was orally administrated (400 mg/kg/day) to HFR and HFRT groups and the same amount of distilled water was orally administered to N and HF groups. Taurine was supplemented by dissolving in feed water (3% w/v).
The activities of glutamate oxaloacetate transaminase and glutamate pyruvate transaminase in serum were lower in HFR and HFRT groups compared to HF group. Thiobarbituric acid reactive substance contents in all groups fed a high fat diet were higher compared to N group. The activities of hepatic antioxidant enzymes were higher in HFR and HFRT groups compared to HF group.
These results suggest that lotus root hot water extract with taurine supplementation shows antioxidant and hepatic protective effects in high fat diet-induced obese rats.
荷花，又称睡莲，是一种广为人知的药用植物，与该植物的其他部分相比，其根茎通常被用作食物。本研究旨在探讨在高脂肪饮食诱导肥胖大鼠中，添加牛磺酸的莲藕热水提取物的抗氧化和肝保护作用。
32 只雄性 Sprague-Dawley 大鼠（4 周龄）随机分为四组（n=8），进行 6 周的实验（正常饮食，N 组；高脂肪饮食，HF 组；高脂肪饮食+莲藕热水提取物，HFR 组；高脂肪饮食+莲藕热水提取物+牛磺酸，HFRT 组）。HFR 和 HFRT 组经口给予莲藕热水提取物（400mg/kg/天），N 和 HF 组经口给予等体积的蒸馏水。牛磺酸通过溶解在饲料水中（3%w/v）添加。
与 HF 组相比，HFR 和 HFRT 组血清中谷氨酸草酰乙酸转氨酶和谷氨酸丙酮酸转氨酶的活性较低。所有高脂肪饮食组的丙二醛含量均高于 N 组。与 HF 组相比，HFR 和 HFRT 组的肝抗氧化酶活性更高。
这些结果表明，添加牛磺酸的莲藕热水提取物在高脂肪饮食诱导的肥胖大鼠中具有抗氧化和肝保护作用。
