Nandhini A T Anitha, Balakrishnan S D, Anuradha C V
Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar 608 002, India.
Indian J Exp Biol. 2002 Sep;40(9):1016-9.
Fructose-fed rats were more susceptible to peroxidative damage as measured by thiobarbituric acid reactive species. The concentrations of lipid peroxides, diene conjugates, lipofuscin and hydroperoxides were significantly higher. The levels of enzymic antioxidants such as vitamin C, vitamin E and glutathione and activities of antioxidant enzymes were significantly lower in fructose-fed rats. When these rats received taurine in drinking water, peroxidative damage was minimal in both plasma and liver. Taurine was effective in inducing the antioxidant potential in fructose-fed rats. Increased peroxidative damage in liver is likely to be associated with fructose dependent pathology, which could be reduced by taurine by enhancing the antioxidant potential.
通过硫代巴比妥酸反应性物质测定，喂食果糖的大鼠更容易受到过氧化损伤。脂质过氧化物、二烯共轭物、脂褐素和氢过氧化物的浓度显著更高。喂食果糖的大鼠体内诸如维生素C、维生素E和谷胱甘肽等酶促抗氧化剂的水平以及抗氧化酶的活性显著更低。当这些大鼠饮用含牛磺酸的水时，血浆和肝脏中的过氧化损伤最小。牛磺酸可有效诱导喂食果糖的大鼠的抗氧化潜能。肝脏中过氧化损伤的增加可能与果糖依赖性病理学有关，而牛磺酸可通过增强抗氧化潜能来减轻这种损伤。
