Roysommuti Sanya, Lerdweeraphon Wichaporn, Malila Pisamai, Jirakulsomchok Dusit, Wyss J Michael
Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Adv Exp Med Biol. 2009;643:145-56. doi: 10.1007/978-0-387-75681-3_15.
The present study investigates the effect of perinatal taurine exposure on renal function in adult, female rats on a high sugar diet. Perinatal taurine depleted (TD), supplemented (TS) or untreated control (C) female offspring were fed normal rat chow and tap water (CW,TDW or TSW) or tap water with 5% glucose (CG, TDG or TSG) after weaning. At 7-8 weeks of age, renal function was studied in the conscious, restrained rats. Mean arterial pressure was significantly higher in TDW, TDG, and TSG rats. Plasma sodium concentration was significantly lower in all glucose treated animals, but the greatest decrease was in TDW rats. Basal renal blood flow was lowest in TSW and TSG, and the responses to a saline load were also lowest in those two groups. These changes were consistent with increased renal vascular resistance. The basal glomerular filtration rate was lowest in TSW, but the responses to a saline load were similar in all of the groups. Water excretion was lower in TSG and TSW, consistent with increased renal tubular water reabsorption. These data suggest that perinatal taurine exposure alters normal renal function and renal responses to dietary sugar in adult female offspring.
本研究调查围产期暴露于牛磺酸对高糖饮食成年雌性大鼠肾功能的影响。围产期牛磺酸缺乏（TD）、补充（TS）或未处理的对照（C）雌性后代在断奶后喂食正常大鼠饲料和自来水（CW、TDW或TSW）或含5%葡萄糖的自来水（CG、TDG或TSG）。在7-8周龄时，对清醒、受限的大鼠进行肾功能研究。TDW、TDG和TSG大鼠的平均动脉压显著更高。所有葡萄糖处理组动物的血浆钠浓度显著降低，但TDW大鼠降低幅度最大。基础肾血流量在TSW和TSG组最低，这两组对生理盐水负荷的反应也最低。这些变化与肾血管阻力增加一致。基础肾小球滤过率在TSW组最低，但所有组对生理盐水负荷的反应相似。TSG和TSW组的水排泄较低，这与肾小管对水的重吸收增加一致。这些数据表明，围产期暴露于牛磺酸会改变成年雌性后代的正常肾功能以及肾脏对饮食中糖的反应。
