Roysommuti Sanya, Suwanich Atchariya, Lerdweeraphon Wichaporn, Thaeomor Atcharaporn, Jirakulsomchok Dusit, Wyss J Michael
Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Adv Exp Med Biol. 2009;643:135-44. doi: 10.1007/978-0-387-75681-3_14.
The present study tests the sex-dependent effect of perinatal taurine exposure on arterial pressure control in adults. Female Sprague-Dawley rats were fed normal rat chow with 3% beta-alanine (taurine depletion,TD), 3% taurine (taurine supplementation,TS) or water alone (C) from conception to weaning. Their male and female offspring were then fed normal rat chow and tap water with 5% glucose (C with glucose, CG; TD with glucose, TDG; TS with glucose, TSG) or water alone (CW, TDW or TSW). At 7-8 weeks of age, they were studied in a conscious condition. Body weights were lower in male and female TDG and male TDW rats. Kidney to body weights increased in female TSW but not TSG. Plasma sodium and potassium were not significantly different among males. Among females, plasma sodium levels were lower in all glucose treated groups while plasma potassium levels were lower only in TDG. Hematocrit, fasting blood glucose, and glucose tolerance were not significantly different between the sexes. Mean arterial pressure increased in male TDG, TSW, and TSG while in the females, mean arterial pressure increased in TabstractDW, TDG, and TSG. Heart rates were not significantly different between the sexes. The present data indicate that perinatal taurine exposure alters arterial pressure control of adult rats and this effect is gender specific.
本研究测试围产期牛磺酸暴露对成年期动脉血压控制的性别依赖性影响。从受孕到断奶，给雌性斯普拉格-道利大鼠喂食含3%β-丙氨酸的普通大鼠饲料（牛磺酸耗竭，TD）、含3%牛磺酸的饲料（牛磺酸补充，TS）或仅喂水（C）。然后，它们的雄性和雌性后代喂食普通大鼠饲料和含5%葡萄糖的自来水（C加葡萄糖，CG；TD加葡萄糖，TDG；TS加葡萄糖，TSG）或仅喂水（CW、TDW或TSW）。在7 - 8周龄时，在清醒状态下对它们进行研究。雄性和雌性TDG大鼠以及雄性TDW大鼠的体重较低。雌性TSW大鼠的肾重与体重之比增加，而TSG大鼠未增加。雄性大鼠的血浆钠和钾无显著差异。在雌性大鼠中，所有葡萄糖处理组的血浆钠水平均较低，而仅TDG组的血浆钾水平较低。两性之间的血细胞比容、空腹血糖和葡萄糖耐量无显著差异。雄性TDG、TSW和TSG大鼠的平均动脉压升高，而在雌性大鼠中，平均动脉压在TDW、TDG和TSG组升高。两性之间的心率无显著差异。目前的数据表明，围产期牛磺酸暴露会改变成年大鼠的动脉血压控制，且这种影响具有性别特异性。
