Department of Physiology Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
J Biomed Sci. 2010 Aug 24;17 Suppl 1(Suppl 1):S30. doi: 10.1186/1423-0127-17-S1-S30.
Perinatal taurine depletion leads to several physiological impairments in adult life, in part, due to taurine's effects on the renin-angiotensin system, a crucial regulator of growth and differentiation during early life. The present study tests the hypothesis that perinatal taurine depletion predisposes adult female rats to impaired baroreceptor control of arterial pressure by altering the renin-angiotensin system. Female Sprague Dawley (SD) rats were fed normal rat chow and from conception to weaning drank 3% beta-alanine in water (taurine depletion, TD) or water alone (Control, C). Female offspring ate a normal rat chow and drank water with (G) or without (W) 5% glucose throughout the experiment. To test the possible role of the renin-angiotensin system, 50% of the rats received captopril (an angiotensin converting enzyme inhibitor, 400 mg/L) from 7 days before parameter measurements until the end of experiment. At 7-8 weeks of age, arterial pressure, heart rate, baroreflex control of heart rate and renal nerve activity were studied in either conscious, freely moving or anesthetized rats. Perinatal taurine depletion did not alter resting mean arterial pressure or heart rate in the adult female offspring that received either high or normal sugar intake. Captopril treatment slightly decreased mean arterial pressure but not heart rate in all groups. Compared to controls, only the TDG rats displayed blunted baroreflex responses. Captopril treatment normalized baroreflex sensitivity in TDG. The present data indicate that in perinatal taurine depleted female rats, the renin-angiotensin system underlines the ability of high sugar intake to blunt baroreceptor responses.
围产期牛磺酸耗竭会导致成年后出现多种生理损伤，部分原因是牛磺酸对肾素-血管紧张素系统的影响，该系统是生命早期生长和分化的关键调节剂。本研究通过检测围产期牛磺酸耗竭是否通过改变肾素-血管紧张素系统而使成年雌性大鼠的压力感受器对动脉血压的控制受损，从而验证了以下假设。雌性 Sprague Dawley（SD）大鼠喂食标准大鼠饲料，从受孕到断奶期间，在饮水中饮用 3%β-丙氨酸（牛磺酸耗竭，TD）或仅饮用水（对照，C）。雌性后代在整个实验过程中进食标准大鼠饲料，饮水中添加（G）或不添加（W）5%葡萄糖。为了测试肾素-血管紧张素系统的可能作用，有 50%的大鼠在参数测量前 7 天开始至实验结束时接受卡托普利（血管紧张素转换酶抑制剂，400mg/L）治疗。在 7-8 周龄时，在清醒、自由活动或麻醉大鼠中研究了动脉血压、心率、心率的压力反射控制和肾神经活性。在摄入高糖或正常糖的成年雌性后代中，围产期牛磺酸耗竭并未改变静息平均动脉压或心率。卡托普利治疗略微降低了所有组的平均动脉压，但对心率没有影响。与对照组相比，只有 TDG 大鼠的压力反射反应减弱。卡托普利治疗使 TDG 大鼠的压力反射敏感性恢复正常。本数据表明，在围产期牛磺酸耗竭的雌性大鼠中，肾素-血管紧张素系统强调了高糖摄入使压力感受器反应迟钝的能力。
