Kumar Vikram, Singh Desh Deepak, Lakhawat Sudarshan Singh, Yasmeen Nusrath, Pandey Aishwarya, Singla Rajeev K
Amity Institute of Biotechnology, Amity University Rajasthan, Jaipur 303002, Rajasthan, India.
INRS, Eau Terre Environnement Research Centre, Québec, QC, Canada.
Evid Based Complement Alternat Med. 2022 Mar 27;2022:6852276. doi: 10.1155/2022/6852276. eCollection 2022.
The incidence of obesity and over bodyweight is emerging as a major health concern. Obesity is a complex metabolic disease with multiple pathophysiological clinical conditions as comorbidities are associated with obesity such as diabetes, hypertension, cardiovascular disorders, sleep apnea, osteoarthritis, some cancers, and inflammation-based clinical conditions. In obese individuals, adipocyte cells increased the expression of leptin, angiotensin, adipocytokines, plasminogen activators, and C-reactive protein. Currently, options for treatment and lifestyle behaviors interventions are limited, and keeping a healthy lifestyle is challenging. Various types of phytochemicals have been investigated for antiobesity potential. Here, we discuss pathophysiology and signaling pathways in obesity, epigenetic regulations, regulatory mechanism, functional ingredients in natural antiobesity products, and therapeutic application of phytochemicals in obesity.
肥胖和超重的发生率正成为一个主要的健康问题。肥胖是一种复杂的代谢性疾病，有多种病理生理临床状况作为合并症与肥胖相关，如糖尿病、高血压、心血管疾病、睡眠呼吸暂停、骨关节炎、某些癌症以及基于炎症的临床状况。在肥胖个体中，脂肪细胞会增加瘦素、血管紧张素、脂肪细胞因子、纤溶酶原激活剂和C反应蛋白的表达。目前，治疗和生活方式行为干预的选择有限，保持健康的生活方式具有挑战性。人们已经研究了各种类型的植物化学物质的抗肥胖潜力。在此，我们讨论肥胖中的病理生理学和信号通路、表观遗传调控、调节机制、天然抗肥胖产品中的功能成分以及植物化学物质在肥胖治疗中的应用。
