Department of Korean Medical Science, School of Korean Medicine, Pusan National University, Yangsan, Gyeongnam 50612, Korea.
Healthy Aging Korean Medical Research Center, Pusan National University, Yangsan, Gyeongnam 50612, Korea.
Molecules. 2021 Mar 12;26(6):1579. doi: 10.3390/molecules26061579.
Muscle fatigue is induced by an acute or chronic physical performance inability after excessive physical activity often associated with lactate accumulation, the end-product of glycolysis. In this study, the water-extracted roots of L., a herbal medicine traditionally used for inflammation and diarrhea, reduced the activities of lactate dehydrogenase A (LDHA) in in vitro enzyme assay myoblast C2C12 cells and murine muscle tissue. Physical performance measured by a treadmill test was improved in the -administrated group. The analysis of mouse serum and tissues showed significant changes in lactate levels. Among the proteins related to energy metabolism-related physical performance, phosphorylated-AMP-activated protein kinase alpha (AMPKα) and peroxisome proliferator-activated receptor-coactivator-1 alpha (PGC-1α) levels were enhanced, whereas the amount of LDHA was suppressed. Therefore, might be a candidate for improving physical performance via inhibiting LDHA and glycolysis.
肌肉疲劳是由过度体力活动后急性或慢性的身体机能障碍引起的，常与乳酸积累有关，乳酸是糖酵解的终产物。在这项研究中，一种传统用于炎症和腹泻的草药 的水提根，降低了体外酶试验肌母细胞 C2C12 细胞和鼠肌肉组织中乳酸脱氢酶 A（LDHA）的活性。跑步机测试测量的身体表现，在 给药组得到了改善。对小鼠血清和组织的分析显示，乳酸水平有显著变化。在与能量代谢相关的身体表现相关的蛋白质中，磷酸化 AMP 激活蛋白激酶α（AMPKα）和过氧化物酶体增殖物激活受体共激活因子-1α（PGC-1α）的水平升高，而 LDHA 的量则受到抑制。因此， 可能是通过抑制 LDHA 和糖酵解来提高身体表现的候选药物。
