Department of Natural Products, National Institute of Pharmaceutical Education and Research, Sector-67, SAS Nagar, Mohali 160062, Punjab, India.
Fitoterapia. 2011 Mar;82(2):173-7. doi: 10.1016/j.fitote.2010.08.016. Epub 2010 Sep 8.
The standardized EtOAc, MeOH and 70% EtOH extracts of Tridax procumbens aerial parts showed significant inhibition of rat paw edema at a medium dose of 200mg/kg and the EtOAC extract was the most active. These extracts were standardized by HPLC with the help of chemical markers. Further, the extracts were evaluated for COX-1 and COX-2 inhibitory activity and EtOAc extract exhibited the highest inhibition of COX-1 and COX-2 at 50 μg/mL. Cent aurein, centaureidin and bergenin were isolated as COX-1 and COX-2 inhibitory principles from the EtOAc extract. The extracts also exhibited antioxidant activity against DPPH and ABTS free radicals. The anti-inflammatory activity of T. procumbens aerial parts could be at least in part due to COX-1, COX-2 enzyme inhibition and free radical-scavenging activities which may be attributed to the presence of flavonoids and other polyphenols in the extracts.
千里光地上部分的标准化 EtOAc、MeOH 和 70% EtOH 提取物在中等剂量 200mg/kg 时对大鼠足肿胀显示出显著的抑制作用，其中 EtOAc 提取物活性最高。这些提取物通过 HPLC 用化学标志物进行标准化。此外，还评估了提取物对 COX-1 和 COX-2 抑制活性的影响，EtOAc 提取物在 50μg/mL 时对 COX-1 和 COX-2 的抑制作用最高。从 EtOAc 提取物中分离到 cent aurein、centaureidin 和 bergin 作为 COX-1 和 COX-2 抑制原理。提取物还表现出对 DPPH 和 ABTS 自由基的抗氧化活性。千里光地上部分的抗炎活性至少部分归因于 COX-1、COX-2 酶抑制和自由基清除活性，这可能归因于提取物中存在类黄酮和其他多酚。
