Larvicidal Evaluation against and Antioxidant and Cytotoxic Potential of the Essential Oil of L. Leaves.

The present study evaluated the antioxidant, cytotoxic, and larvicidal potential of the essential oil of leaves, as well as identified the compounds present in the essential oil. The antioxidant activity was evaluated by the sequestration method of 2,2-diphenyl-1-picrylhydrazyl radical, the cytotoxic activity was evaluated using , the larvicidal bioassay was performed with larvae in the third stage of development of the mosquito, and the identification of the metabolites was performed by gas chromatography coupled to the mass spectrometer (GC-MS). The phytochemical oil analysis showed the presence of 20 compounds, with thymol and -terpinene being the main ones. It presented antioxidant activity with an IC of 194.51 g mL, demonstrating antioxidant activity in the highest concentrations tested. It presented low cytotoxic activity against , with an LC of 1238.67 g mL, demonstrating atoxicity in the concentrations tested. The essential oil presented good larvicidal activity when compared to the literature, with an LC = 79.0 g mL in 24 hours and LC of 69.15 g mL in 48 hours. In this way, it was possible to identify that the essential oil of the leaves of presented potential for the development of a natural larvicide, as well as antioxidant activity satisfactory to the radical DPPH and low toxicity to .