模拟转录因子的小分子调节剂。
Small-molecule regulators that mimic transcription factors.
作者信息
Rodríguez-Martínez José A, Peterson-Kaufman Kimberly J, Ansari Aseem Z
机构信息
Department of Biochemistry and Genome Center, University of Wisconsion-Madison, WI 53706, USA.
出版信息
Biochim Biophys Acta. 2010 Oct-Dec;1799(10-12):768-74. doi: 10.1016/j.bbagrm.2010.08.010. Epub 2010 Sep 6.
Abstract
Transcription factors (TFs) are responsible for decoding and expressing the information stored in the genome, which dictates cellular function. Creating artificial transcription factors (ATFs) that mimic endogenous TFs is a major goal at the interface of biology, chemistry, and molecular medicine. Such molecular tools will be essential for deciphering and manipulating transcriptional networks that lead to particular cellular states. In this minireview, the framework for the design of functional ATFs is presented and current challenges in the successful implementation of ATFs are discussed.
摘要
转录因子（TFs）负责解码和表达存储在基因组中的信息，而基因组信息决定了细胞功能。创建能够模拟内源性转录因子的人工转录因子（ATFs）是生物学、化学和分子医学交叉领域的一个主要目标。此类分子工具对于解读和操控导致特定细胞状态的转录网络至关重要。在这篇小型综述中，我们介绍了功能性人工转录因子的设计框架，并讨论了在成功应用人工转录因子过程中当前面临的挑战。
相似文献
1
Small-molecule regulators that mimic transcription factors.模拟转录因子的小分子调节剂。
Biochim Biophys Acta. 2010 Oct-Dec;1799(10-12):768-74. doi: 10.1016/j.bbagrm.2010.08.010. Epub 2010 Sep 6.
2
From Peptides to Peptidomimetics: A Strategy Based on the Structural Features of Cyclopropane.从肽到拟肽：基于环丙烷结构特征的策略。
Chemistry. 2017 Oct 17;23(58):14394-14409. doi: 10.1002/chem.201702119. Epub 2017 Aug 22.
3
The new biomimetic chemistry: artificial transcription factors.新型仿生化学：人工转录因子
ACS Chem Biol. 2007 Sep 21;2(9):599-601. doi: 10.1021/cb700183s.
4
Reprogramming cell fate with a genome-scale library of artificial transcription factors.利用人工转录因子的全基因组文库重编程细胞命运。
Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):E8257-E8266. doi: 10.1073/pnas.1611142114. Epub 2016 Dec 5.
5
Recent development of small antimicrobial peptidomimetics.近年来小分子抗菌肽类似物的研究进展。
Future Med Chem. 2012 Sep;4(14):1853-62. doi: 10.4155/fmc.12.111.
6
Peptidomimetic toolbox for drug discovery.用于药物发现的肽模拟工具包。
Chem Soc Rev. 2020 Jun 7;49(11):3262-3277. doi: 10.1039/d0cs00102c. Epub 2020 Apr 7.
7
Reprogramming cell fate with artificial transcription factors.用人工转录因子重编程细胞命运。
FEBS Lett. 2018 Mar;592(6):888-900. doi: 10.1002/1873-3468.12993. Epub 2018 Feb 11.
8
Peptide and peptidomimetic ligands for CXC chemokine receptor 4 (CXCR4).针对 CXC 趋化因子受体 4 (CXCR4) 的肽和拟肽配体。
Org Biomol Chem. 2012 Aug 14;10(30):5720-31. doi: 10.1039/c2ob25107h. Epub 2012 Apr 19.
9
Development of Macrocyclic Peptidomimetics Containing Constrained α,α-Dialkylated Amino Acids with Potent and Selective Activity at Human Melanocortin Receptors.开发含有约束α,α-二取代氨基酸的大环肽拟肽，对人黑素皮质素受体具有强效和选择性活性。
J Med Chem. 2018 May 10;61(9):4263-4269. doi: 10.1021/acs.jmedchem.8b00488. Epub 2018 Apr 25.
10
Antibacterial evaluation of structurally amphipathic, membrane active small cationic peptidomimetics: synthesized by incorporating 3-amino benzoic acid as peptidomimetic element.结构两亲性、膜活性的阳离子小肽模拟物的抗菌评价：通过引入 3-氨基苯甲酸作为肽模拟元件合成。
Eur J Med Chem. 2014 Aug 18;83:102-15. doi: 10.1016/j.ejmech.2014.06.023. Epub 2014 Jun 12.
引用本文的文献
1
Concise review: Cancer cell reprogramming and therapeutic implications.简要综述：癌细胞重编程及其治疗意义。
Transl Oncol. 2022 Oct;24:101503. doi: 10.1016/j.tranon.2022.101503. Epub 2022 Aug 4.
2
Improving motor neuron-like cell differentiation of hEnSCs by the combination of epothilone B loaded PCL microspheres in optimized 3D collagen hydrogel.通过载有埃博霉素 B 的 PCL 微球与优化的 3D 胶原水凝胶的组合，提高 hEnSCs 的运动神经元样细胞分化。
Sci Rep. 2021 Nov 5;11(1):21722. doi: 10.1038/s41598-021-01071-2.
3
Potential of transposon-mediated cellular reprogramming towards cell-based therapies.转座子介导的细胞重编程在基于细胞疗法中的潜力。
World J Stem Cells. 2020 Jul 26;12(7):527-544. doi: 10.4252/wjsc.v12.i7.527.
4
Cancer cell reprogramming: a promising therapy converting malignancy to benignity.癌细胞重编程：一种有前途的疗法，可将恶性转化为良性。
Cancer Commun (Lond). 2019 Aug 29;39(1):48. doi: 10.1186/s40880-019-0393-5.
5
Characterization of CADD522, a small molecule that inhibits RUNX2-DNA binding and exhibits antitumor activity.CADD522的特性研究，CADD522是一种抑制RUNX2与DNA结合并具有抗肿瘤活性的小分子。
Oncotarget. 2017 Aug 10;8(41):70916-70940. doi: 10.18632/oncotarget.20200. eCollection 2017 Sep 19.
6
Nucleosome distortion as a possible mechanism of transcription activation domain function.核小体畸变作为转录激活域功能的一种可能机制。
Epigenetics Chromatin. 2016 Sep 20;9:40. doi: 10.1186/s13072-016-0092-2. eCollection 2016.
7
Targeted Inhibition of Snail Activity in Breast Cancer Cells by Using a Co(III) -Ebox Conjugate.使用钴（III）-E盒共轭物靶向抑制乳腺癌细胞中的蜗牛蛋白活性
Chembiochem. 2015 Sep 21;16(14):2065-72. doi: 10.1002/cbic.201500289. Epub 2015 Aug 25.
8
Integrating epigenetic modulators into NanoScript for enhanced chondrogenesis of stem cells.将表观遗传调节剂整合到NanoScript中以增强干细胞的软骨生成。
J Am Chem Soc. 2015 Apr 15;137(14):4598-601. doi: 10.1021/ja511298n. Epub 2015 Apr 2.
9
Controlling gene networks and cell fate with precision-targeted DNA-binding proteins and small-molecule-based genome readers.利用精准靶向DNA结合蛋白和小分子基因组读取器控制基因网络和细胞命运。
Biochem J. 2014 Sep 15;462(3):397-413. doi: 10.1042/BJ20140400.
10
NanoScript: a nanoparticle-based artificial transcription factor for effective gene regulation.纳米脚本：一种基于纳米颗粒的用于有效基因调控的人工转录因子。
ACS Nano. 2014 Sep 23;8(9):8959-67. doi: 10.1021/nn501589f. Epub 2014 Aug 20.
本文引用的文献
1
Targeted DNA methylation by a DNA methyltransferase coupled to a triple helix forming oligonucleotide to down-regulate the epithelial cell adhesion molecule.通过与三链形成寡核苷酸偶联的 DNA 甲基转移酶靶向 DNA 甲基化，下调上皮细胞黏附分子。
Bioconjug Chem. 2010 Jul 21;21(7):1239-45. doi: 10.1021/bc1000388.
2
Synthetic biology: applications come of age.合成生物学：应用走向成熟。
Nat Rev Genet. 2010 May;11(5):367-79. doi: 10.1038/nrg2775.
3
Modular system for the construction of zinc-finger libraries and proteins.模块化锌指文库和蛋白质构建系统。
Nat Protoc. 2010 Apr;5(4):791-810. doi: 10.1038/nprot.2010.34. Epub 2010 Apr 1.
4
The discovery of zinc fingers and their applications in gene regulation and genome manipulation.锌指结构的发现及其在基因调控和基因组操作中的应用。
Annu Rev Biochem. 2010;79:213-31. doi: 10.1146/annurev-biochem-010909-095056.
5
Specificity landscapes of DNA binding molecules elucidate biological function.DNA 结合分子的特异性景观阐明了生物学功能。
Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4544-9. doi: 10.1073/pnas.0914023107. Epub 2010 Feb 22.
6
Breaking the code of DNA binding specificity of TAL-type III effectors.破解 TAL 型 III 效应物 DNA 结合特异性的密码。
Science. 2009 Dec 11;326(5959):1509-12. doi: 10.1126/science.1178811.
7
A simple cipher governs DNA recognition by TAL effectors.一个简单的密码规则控制着 TAL 效应因子对 DNA 的识别。
Science. 2009 Dec 11;326(5959):1501. doi: 10.1126/science.1178817.
8
Chemical biology: A Notch above other inhibitors.化学生物学：比其他抑制剂更胜一筹。
Nature. 2009 Nov 12;462(7270):171-3. doi: 10.1038/462171a.
9
Repression of DNA-binding dependent glucocorticoid receptor-mediated gene expression.DNA结合依赖性糖皮质激素受体介导的基因表达的抑制
Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16598-603. doi: 10.1073/pnas.0909192106. Epub 2009 Sep 15.
10
Investigation of the relative cellular permeability of DNA-binding pyrrole-imidazole polyamides.DNA结合型吡咯-咪唑聚酰胺的相对细胞通透性研究。
J Med Chem. 2009 Aug 13;52(15):4604-12. doi: 10.1021/jm9002999.
Zotero 插件