Vial T, Laine V, Delcombel M, Goubier C, Galland M C, Mallaret M, Descotes J
Centre de Pharmaco-Toxicovigilance, Hôpital E. Herriot, Lyon.
Therapie. 1990 Nov-Dec;45(6):509-12.
We describe five cases of vasculitis noted a few days after influenza vaccination. This complication has occurred in four women, and the mean age was 76 years. Although cutaneous biopsy has confirmed leucocytoclasic vasculitis in only one case, the clinical characteristics were evocative in the other cases. No systemic complication were noted. Spontaneous retrocession was noted in four patients and following corticosteroids once. To our knowledge only few cases of vasculitis has been previously reported after influenza vaccination. The mechanisms are unknown but preservatives may have some responsibilities.
我们描述了5例在流感疫苗接种几天后出现血管炎的病例。这种并发症发生在4名女性身上,平均年龄为76岁。虽然皮肤活检仅在1例中确诊为白细胞破碎性血管炎,但其他病例的临床特征也具有提示性。未发现全身性并发症。4例患者出现自发消退,1例患者在使用皮质类固醇后消退。据我们所知,此前仅有少数几例流感疫苗接种后血管炎的病例报道。其机制尚不清楚,但防腐剂可能有一定责任。