Marr Robert A, Thomas Rosanne M, Peterson Daniel A
Department of Neuroscience, Center for Stem Cell & Regenerative Medicine, Rosalind Franklin University of Medicine & Science, 3333 Green Bay Road, North Chicago, IL 60064, USA.
Future Neurol. 2010 Jul 1;5(4):527-541. doi: 10.2217/FNL.10.33.
Neurogenesis is the process by which new neural cells are generated from a small population of multipotent stem cells in the adult CNS. This natural generation of new cells is limited in its regenerative capabilities and also declines with age. The use of stem cells in the treatment of neurodegenerative disease may hold great potential; however, the age-related incidence of many CNS diseases coincides with reduced neurogenesis. This review concisely summarizes current knowledge related to adult neurogenesis and its alteration with aging and examines the feasibility of using stem cell and gene therapies to combat diseases of the CNS with advancing age.
神经发生是指在成体中枢神经系统中，由一小群多能干细胞产生新神经细胞的过程。这种新细胞的自然生成在其再生能力方面是有限的，并且也会随着年龄的增长而下降。干细胞在神经退行性疾病治疗中的应用可能具有巨大潜力；然而，许多中枢神经系统疾病与年龄相关的发病率与神经发生减少相吻合。本综述简要总结了与成体神经发生及其随衰老而变化相关的当前知识，并探讨了使用干细胞和基因疗法来对抗随着年龄增长而出现的中枢神经系统疾病的可行性。
