Department of Neurology, Nanfang Hospital, Nanfang Medical University, Guangzhou 510515, China.
Neurosci Bull. 2010 Feb;26(1):55-65. doi: 10.1007/s12264-010-0716-7.
The benefits of dietary restriction (DR) on health and aging prevention have been well recognized. Recent studies suggest that DR may enhance brain functions including learning and memory, synaptic plasticity, and neurogenesis, all of which are associated with brain health. Under the stress stimulated by DR, a favorable environment is established for facilitating neuronal plasticity, enhancing cognitive function, stimulating neurogenesis and regulating inflammatory response. DR-induced expressions of factors such as heat shock proteins (HSPs), neurotrophic factors, and Sirtuin1 (SIRT1) are responsible for the effect of DR on the brain. Due to the difficulty in practising long-term DR in human, the potential mimics of DR are also discussed.
限制饮食（DR）对健康和衰老预防的益处已得到充分认可。最近的研究表明，DR 可能增强大脑功能，包括学习和记忆、突触可塑性和神经发生，所有这些都与大脑健康有关。在 DR 刺激的应激下，为促进神经元可塑性、增强认知功能、刺激神经发生和调节炎症反应创造了有利环境。DR 诱导的热休克蛋白（HSPs）、神经营养因子和 Sirtuin1（SIRT1）等因子的表达负责 DR 对大脑的影响。由于长期在人体中实行 DR 较为困难，因此也讨论了 DR 的潜在模拟物。
