2型肽基精氨酸脱亚氨酶在青光眼性视神经中过度表达。
Peptidylarginine deiminase type 2 is over expressed in the glaucomatous optic nerve.
作者信息
Cafaro Thamara A, Santo Stefanía, Robles Lucena A, Crim Nicolás, Urrets-Zavalia Julio A, Serra Horacio M
机构信息
CIBICI, Faculty of Chemistry, National University of Córdoba, Argentina.
出版信息
Mol Vis. 2010 Aug 17;16:1654-8.
PURPOSE
To determine levels of Peptidyl arginine deiminase 2 (PAD2) and its product protein-bound citrulline in cadaver eyes that suffered from normal tension glaucoma (NTG) compared to primary open angle glaucoma (POAG), and controls.
METHODS
Western analysis, ELISA, and immunohistochemical analysis were performed with human tissues.
RESULTS
We report over expression of PAD2 and higher levels of its product protein-bound citrulline in the optic nerve of normal tension glaucoma patients (NTG).
CONCLUSIONS
This is the first report demonstrating that like in POAG, NTG also possesses elevated levels of both PAD2 and protein-bound citrulline.
目的
与原发性开角型青光眼（POAG）及对照组相比，测定患正常眼压性青光眼（NTG）的尸体眼内肽基精氨酸脱亚氨酶2（PAD2）及其产物蛋白结合瓜氨酸的水平。
方法
对人体组织进行蛋白质免疫印迹分析、酶联免疫吸附测定（ELISA）及免疫组织化学分析。
结果
我们报告正常眼压性青光眼（NTG）患者视神经中PAD2过表达及其产物蛋白结合瓜氨酸水平更高。
结论
这是首份表明与POAG一样，NTG中PAD2和蛋白结合瓜氨酸水平也升高的报告。
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