Seiler Gabriela S, Rhodes James, Cianciolo Rachel, Casal Margret L
Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, 3900 Spruce Street, Philadelphia, PA 19104-6010, USA.
Vet Radiol Ultrasound. 2010 Jul-Aug;51(4):453-7. doi: 10.1111/j.1740-8261.2010.01674.x.
Renal dysplasia is a hereditary disease characterized by abnormal differentiation of renal tissue. The ultrasonographic appearance of dysplastic canine kidneys has been reported in the late stage of the disease where inflammatory and degenerative changes are already present and the dogs are in chronic renal failure. In this study, we describe the ultrasonographic appearance of the kidneys of five related Cairn Terriers affected with renal dysplasia before the onset of clinical or laboratory evidence of renal failure. Common findings included poor corticomedullary definition and multifocal hyperechoic speckles in the renal medulla, or a diffusely hyperechoic medulla. Severity of ultrasonographic changes was related to the severity of histopathologic findings. The ability to detect dysplastic changes before clinical signs develop makes ultrasound a potentially useful screening method for canine renal dysplasia.
肾发育不良是一种以肾组织异常分化为特征的遗传性疾病。已有报道称，在患有肾发育不良的犬类疾病晚期，即炎症和退行性变化已经出现且犬处于慢性肾衰竭时，其发育不良肾脏的超声表现。在本研究中，我们描述了五只患有肾发育不良的相关凯恩梗犬在出现肾衰竭的临床或实验室证据之前肾脏的超声表现。常见表现包括肾皮质髓质分界不清以及肾髓质内多发高回声斑点，或弥漫性高回声髓质。超声变化的严重程度与组织病理学结果的严重程度相关。在临床症状出现之前就能检测到发育不良变化，这使得超声成为一种潜在有用的犬肾发育不良筛查方法。
