托品甾醇，来自海洋海绵 Topsentia sp 的 24-异丙基甾醇。
Topsentinols, 24-isopropyl steroids from the marine sponge Topsentia sp.
机构信息
Department of Chemistry, University of Hawaii at Manoa, Honolulu, Hawaii 96822, USA.
出版信息
J Nat Prod. 2010 Sep 24;73(9):1597-600. doi: 10.1021/np100374b.
Abstract
Three isopropyl steroids, topsentinols K, L, and K trisulfate (1-3), were isolated from an undescribed species of Topsentia. The structures of the new compounds were determined by extensive 1D and 2D NMR experiments and mass spectrometry measurements. Topsentinol K trisulfate (3) inhibited the aspartic protease BACE1, although in a detergent-dependent manner suggestive of nonspecific aggregation.
摘要
从一个未被描述的托品属物种中分离得到三种异丙基甾体，分别为托品醇 K、L 和 K 三硫酸盐（1-3）。通过广泛的 1D 和 2D NMR 实验以及质谱测量确定了新化合物的结构。托品醇 K 三硫酸盐（3）抑制天冬氨酸蛋白酶 BACE1，但在去污剂依赖性方式下，提示非特异性聚集。
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