Department of Chemistry, University of Hawaii at Manoa, Honolulu, Hawaii 96822.
J Nat Prod. 2010 Jun 25;73(6):1188-91. doi: 10.1021/np100203x.
Eight pentacyclic compounds, xestosaprols F-M (1-8), were isolated from a marine sponge belonging to the genus Xestospongia. The structures of these new compounds were determined on the basis of extensive analyses of NMR experiments and mass spectrometric measurements. These compounds inhibited the aspartic protease BACE1 at moderate levels in a dose-dependent manner.
从属于 Xestospongia 属的一种海绵中分离得到 8 种五环化合物，分别命名为 xestosaprols F-M（1-8）。基于核磁共振实验和质谱分析等手段，鉴定了这些新化合物的结构。这些化合物能够剂量依赖性地中度抑制天冬氨酸蛋白酶 BACE1。
