越南海洋海绵来源的新三硫酸甾醇及其 PSA 表达和葡萄糖摄取抑制活性。
New Trisulfated Steroids from the Vietnamese Marine Sponge and Their PSA Expression and Glucose Uptake Inhibitory Activities.
机构信息
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia.
Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumorzentrum, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
出版信息
Mar Drugs. 2019 Jul 27;17(8):445. doi: 10.3390/md17080445.
Seven new unusual polysulfated steroids-topsentiasterol sulfate G (), topsentiasterol sulfate I (), topsentiasterol sulfate H (), bromotopsentiasterol sulfate D (), dichlorotopsentiasterol sulfate D (), bromochlorotopsentiasterol sulfate D (), and 4-hydroxyhalistanol sulfate C (), as well as three previously described-topsentiasterol sulfate D (), chlorotopsentiasterol sulfate D () and iodotopsentiasterol sulfate D () have been isolated from the marine sponge . Structures of these compounds were determined by detailed analysis of 1D- and 2D-NMR and HRESIMS data, as well as chemical transformations. The effects of the compounds on human prostate cancer cells PC-3 and 22Rv1 were investigated.
从海洋海绵中分离得到了七种新的非寻常多硫酸酯甾体 - topsentiasterol 硫酸盐 G ()、topsentiasterol 硫酸盐 I ()、topsentiasterol 硫酸盐 H ()、bromotopsentiasterol 硫酸盐 D ()、dichlorotopsentiasterol 硫酸盐 D ()、bromochlorotopsentiasterol 硫酸盐 D () 和 4-hydroxyhalistanol 硫酸盐 C ()，以及三种先前描述的 - topsentiasterol 硫酸盐 D ()、chlorotopsentiasterol 硫酸盐 D () 和 iodotopsentiasterol 硫酸盐 D ()。通过详细分析 1D 和 2D-NMR 以及 HRESIMS 数据以及化学转化，确定了这些化合物的结构。研究了这些化合物对人前列腺癌细胞 PC-3 和 22Rv1 的影响。
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