血清白蛋白与人类动脉粥样硬化斑块的生物分子氧化损伤。
Serum albumin and biomolecular oxidative damage of human atherosclerotic plaques.
机构信息
Dipartimento di Medicina e Scienze dell'Invecchiamento, Università G. d'Annunzio, Italy.
出版信息
Clin Biochem. 2010 Dec;43(18):1458-60. doi: 10.1016/j.clinbiochem.2010.08.025. Epub 2010 Aug 31.
OBJECTIVES
To investigate the association of serum albumin (SA) with oxidative damage of human atherosclerotic plaques and the severity of atherosclerosis.
DESIGN AND METHODS
Correlation of the levels of SA with those of lipid and protein oxidation of endarterectomy-removed carotid atherosclerotic plaques; SA and plaque oxidative biomarkers comparison between 2 groups of patients with different severity of atherosclerotic carotid stenosis, i.e. <90% (group I) or ≥90% (group II).
RESULTS
SA was strongly inversely correlated with plaque oxidative damage; SA was lower and plaque oxidative damage higher in group II than group I.
CONCLUSIONS
Lowered SA is associated with oxidative damage of atherosclerotic plaques and the severity of atherosclerosis.
目的
探讨血清白蛋白（SA）与人类动脉粥样硬化斑块氧化损伤及动脉粥样硬化严重程度的关系。
设计与方法
分析颈动脉内膜切除术切除的动脉粥样硬化斑块中 SA 水平与脂质和蛋白质氧化水平的相关性；比较不同程度动脉粥样硬化性颈动脉狭窄患者（狭窄程度＜90%（组 I）或≥90%（组 II））之间的 SA 与斑块氧化生物标志物。
结果
SA 与斑块氧化损伤呈强负相关；组 II 的 SA 低于组 I，斑块氧化损伤高于组 I。
结论
较低的 SA 与动脉粥样硬化斑块的氧化损伤和动脉粥样硬化的严重程度有关。
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