Allergy and Clinical Immunology Unit, Tel Aviv Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Autoimmun Rev. 2010 Dec;10(2):112-5. doi: 10.1016/j.autrev.2010.08.013. Epub 2010 Aug 31.
The existence of a population of lymphocytes with suppressor activity able to inhibit immune responses has been widely studied. The greatest advances were made when researchers proposed markers, such as CD25 and Foxp3, for identifying those suppressor T cells. Regulatory T cells (Tregs) represent approximately 10% of the CD4 T cells and are able to suppress the immune responses to self and foreign antigens. Tregs can develop and acquire a suppressor phenotype in the thymus (natural Tregs) or be induced in the periphery followed certain activation and antigen presentations conditions (induced Tregs). These cells can suppress the immunological system by two principal pathways: the direct suppression of the target cells by cell-contact, and by the secretion of suppressor cytokines. This review summarizes the published data on Tregs and its suggested role in various states of health and disease.
抑制性活性淋巴细胞群体的存在能够抑制免疫反应，这一现象已经得到了广泛的研究。当研究人员提出了诸如 CD25 和 Foxp3 等标记物来识别这些抑制性 T 细胞时，取得了最大的进展。调节性 T 细胞（Tregs）占 CD4 T 细胞的约 10%，能够抑制对自身和外来抗原的免疫反应。Tregs 可以在胸腺中发育并获得抑制表型（天然 Tregs），也可以在外周诱导，随后在特定的激活和抗原呈递条件下诱导（诱导 Tregs）。这些细胞可以通过两种主要途径抑制免疫系统：通过细胞接触直接抑制靶细胞，以及通过分泌抑制性细胞因子。这篇综述总结了关于 Tregs 的已发表数据及其在各种健康和疾病状态下的作用。
