Doelman C J, Borm P J, Bast A
Department of Pharmacochemistry, Faculty of Chemistry, Vrije Universiteit, Amsterdam, The Netherlands.
Agents Actions Suppl. 1990;31:81-4. doi: 10.1007/978-3-0348-7379-6_10.
The widely used plasticiser di(2-ethylhexyl)phthalate (DEHP) has been reported to have some toxicological effects on pulmonary tissue. Inhalation of DEHP may cause pulmonary edema and bronchial asthma. Moreover intravenous injection of DEHP induces pulmonary inflammation and hemorrhage of the lungs. We now report that DEHP might cause bronchial hyperresponsiveness. The metabolite of DEHP mono(2-ethylhexyl)phthalate (MEHP) induces in vitro a dose-dependent increase in -log EC50 for methacholine dose response curves in rat tracheal tissue. Moreover MEHP induces a decrease in maximal effect of the methacholine dose response curve. We concluded that DEHP due to the formation of MEHP in vivo, may cause bronchial hyperresponsiveness.
广泛使用的增塑剂邻苯二甲酸二（2-乙基己基）酯（DEHP）据报道对肺组织有一些毒理学作用。吸入DEHP可能导致肺水肿和支气管哮喘。此外，静脉注射DEHP会引发肺部炎症和肺出血。我们现在报告DEHP可能会导致支气管高反应性。DEHP的代谢产物单（2-乙基己基）邻苯二甲酸酯（MEHP）在体外可使大鼠气管组织中乙酰甲胆碱剂量反应曲线的-log EC50呈剂量依赖性增加。此外，MEHP会导致乙酰甲胆碱剂量反应曲线的最大效应降低。我们得出结论，由于DEHP在体内形成MEHP，可能会导致支气管高反应性。
