Oie L, Hersoug L G, Madsen J O
National Institute of Public Health, Department of Population Health Sciences, Oslo, Norway.
Environ Health Perspect. 1997 Sep;105(9):972-8. doi: 10.1289/ehp.97105972.
The plasticizer di(2-ethylhexyl) phthalate (DEHP) is widely used in building materials. DEHP is identified as the major plasticizer exposure in dwellings. We provide evidence that inhalation exposure to DEHP as aerosols adsorbed to particulate matter is as important, or more important, than vapor phase exposure. The particulate inhalation exposure to DEHP is considered to be significant due to its low clearance and extensive penetration into the pulmonary region. DEHP is capable of creating high local concentrations in the airways at the deposition site with subsequent local effects. The proposed mechanism of effect states that mono(2-ethylhexyl) phthalate (MEHP), the primary hydrolysis product of DEHP, mimics the inducing prostaglandins (PG) PGD(2), 9alpha,11betaPGF2, and PGF2alpha, and thromboxanes in the lungs, thereby increasing the risk of inducing inflammation in the airways, which is a characteristic of asthma.
增塑剂邻苯二甲酸二（2-乙基己基）酯（DEHP）广泛应用于建筑材料中。DEHP被认为是住宅中主要的增塑剂暴露源。我们提供的证据表明，吸入吸附在颗粒物上的DEHP气溶胶与气相暴露一样重要，甚至更为重要。由于DEHP清除率低且能广泛渗透到肺部区域，因此通过颗粒物吸入接触DEHP被认为具有重要意义。DEHP能够在沉积部位的气道中产生高局部浓度，继而产生局部效应。所提出的作用机制表明，DEHP的主要水解产物单（2-乙基己基）邻苯二甲酸酯（MEHP）在肺部模拟诱导前列腺素（PG）PGD2、9α,11βPGF2和PGF2α以及血栓素，从而增加诱发气道炎症的风险，而气道炎症是哮喘的一个特征。
