由羊瘙痒病和克雅氏病感染的脑组织提取物诱导的细胞融合。
Cell fusion induced by scrapie and Creutzfeldt-Jakob virus-infected brain preparations.
作者信息
Kidson C, Moreau M C, Asher D M, Brown P W, Coon H G, Gajdusek D C, Gibbs C J
出版信息
Proc Natl Acad Sci U S A. 1978 Jun;75(6):2969-71. doi: 10.1073/pnas.75.6.2969.
Abstract
Cell fusion was induced by brain extracts containing the scrapie virus and the virus of Creutzfeldt-Jakob disease. The assay involved quantitation of colony-forming ability in a double selection system, strandardized against fusion induced by Sendai virus. Correlation between the logarithm of virus dilution and the hybrid colony number gave similar curves for scrapie virus and Sendai virus. Fusion induction may explain some aspects of pathogenesis in these diseases and provide a potential in vitro assay.
摘要
含有羊瘙痒病病毒和克雅氏病病毒的脑提取物可诱导细胞融合。该检测方法涉及在双重选择系统中对集落形成能力进行定量，以仙台病毒诱导的融合为标准进行标准化。病毒稀释对数与杂交集落数之间的相关性，对于羊瘙痒病病毒和仙台病毒给出了相似的曲线。融合诱导可能解释了这些疾病发病机制的某些方面，并提供了一种潜在的体外检测方法。
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