Bădulescu Fl, Crişan Anda, Bădulescu Adriana, Schenker M
Department of Medical Oncology, University of Medicine and Pharmacy of Craiova, Romania.
Rom J Morphol Embryol. 2010;51(3):437-40.
Human papillomavirus (HPV) is a small circular DNA-virus and the high-risk types 16, 18 is implicated in oncogenesis of head and neck cancer--especially oropharynx (tonsil and base of tongue), poorly differentiated (the basaloid type), locoregional advanced stage, poorly differentiated, at the younger male, non-smokers, non-drinkers, sexual behaviors. The prognostic is favorable of human papillomavirus tumor status for patients with oropharynx squamous cell carcinoma treated with radiotherapy (accelerated fractionation without total dose reduction). The impact of HPV-vaccination (ACIP 2007) decreasing the incidence of oropharyngeal cancer, but that patients HPV-positive, have good prognostic in generally (two-year overall survival: 95%, two-year progression-free survival: 88%), therefore HPV-vaccination in routine practice it is controversy.
人乳头瘤病毒（HPV）是一种小型环状DNA病毒，高危型16、18型与头颈癌的发生有关，尤其是口咽癌（扁桃体和舌根）、低分化（基底样型）、局部晚期、低分化、年轻男性、不吸烟者、不饮酒者及性行为。对于接受放疗（加速分割且不降低总剂量）治疗的口咽鳞状细胞癌患者，人乳头瘤病毒肿瘤状态的预后良好。HPV疫苗接种（ACIP 2007）对降低口咽癌发病率有影响，但HPV阳性患者总体预后良好（两年总生存率：95%，两年无进展生存率：88%），因此在常规实践中HPV疫苗接种存在争议。
