确定口咽鳞状细胞癌人乳头瘤病毒状态的辅助研究：综述

Cantley Richard L, Gabrielli Eleonora, Montebelli Francesco, Cimbaluk David, Gattuso Paolo, Petruzzelli Guy

Department of Pathology, Rush University Medical Center, 1850 W. Harrison Street, 570 Jelke Building, Chicago, IL 60612, USA.

Patholog Res Int. 2011;2011:138469. doi: 10.4061/2011/138469. Epub 2011 Jul 3.

Squamous cell carcinoma (SCC) of the oral cavity and pharynx represents the sixth most common form of malignancy worldwide. A significant proportion of these cases are related to human papillomavirus (HPV) infection. In general, HPV-associated SCC is more commonly nonkeratinizing and poorly differentiated, whereas non-HPV-associated SCC is typically keratinizing and moderately differentiated. Nevertheless, significant overlap in morphology is seen between these two forms of SCC. The purpose of this paper is to highlight the utility of ancillary studies in the establishment of HPV status of oropharyngeal SCC, including p16 immunohistochemistry, high-risk HPV in situ hybridization, polymerase chain reaction, and newer HPV detection modalities.

口腔和咽鳞状细胞癌（SCC）是全球第六大常见恶性肿瘤形式。这些病例中有很大一部分与人类乳头瘤病毒（HPV）感染有关。一般来说，HPV相关的SCC更常见为非角化且分化差，而非HPV相关的SCC通常为角化且中度分化。然而，这两种形式的SCC在形态上有明显重叠。本文的目的是强调辅助研究在确定口咽SCC的HPV状态中的作用，包括p16免疫组织化学、高危HPV原位杂交、聚合酶链反应以及更新的HPV检测方法。