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¹¹C]乙酸盐 PET/CT 可用于可视化髋关节置换术后骨骼肌的运动参与、功能障碍和恢复情况；初步结果。

[¹¹C]acetate PET/CT visualizes skeletal muscle exercise participation, impaired function, and recovery after hip arthroplasty; first results.

机构信息

Service of Nuclear Medicine, University Hospital of Geneva, Geneva, Switzerland.

出版信息

Mol Imaging Biol. 2011 Aug;13(4):793-9. doi: 10.1007/s11307-010-0415-9. Epub 2010 Aug 31.

DOI:10.1007/s11307-010-0415-9
PMID:20809207
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3128267/
Abstract

PURPOSE

Based on skeletal muscle acetate physiology we aimed studying muscle function after hip arthroplasty with [(11)C]acetate PET.

PROCEDURES

Two male patients were investigated 3 and 12 weeks after hip arthroplasty with muscle [(11)C]acetate PET/CT performed at rest and exercise. Median muscle SUV(mean) were calculated on three non-consecutive transverse PET slices.

RESULTS

The four exercise PET/CT showed, compared with rest, consistent increase in [(11)C]acetate uptake in active muscles contralateral to surgery. On the arthroplasty side most muscles showed symmetric activity increase under exercise both at 3 and 12 weeks after surgery, but four muscles showed only minor activity increase at 3 weeks. At 3 months, functional recovery of the latter four muscles was observed.

CONCLUSION

Consistent increase in [(11)C]acetate uptake in healthy muscles under exercise compared with rest was observed by PET/CT. Transiently impaired muscle function 3 weeks after surgery recovered at 3 months. These first observations merit further investigation.

摘要

目的

基于骨骼肌醋酸盐生理学原理，我们旨在通过 [(11)C]醋酸盐 PET 研究髋关节置换术后的肌肉功能。

方法

两名男性患者在髋关节置换术后 3 周和 12 周时接受肌肉 [(11)C]醋酸盐 PET/CT 检查，在休息和运动时进行。在三个非连续的横断 PET 切片上计算中位数肌肉 SUV（平均值）。

结果

与休息时相比，在手术对侧的活动肌肉中，在 4 次运动 PET/CT 中 [(11)C]醋酸盐摄取一致增加。在手术后 3 周和 12 周，手术侧的大多数肌肉在运动下均表现出对称的活性增加，但有 4 块肌肉在 3 周时仅表现出轻微的活性增加。在 3 个月时，发现后 4 块肌肉的功能恢复。

结论

通过 PET/CT 观察到，在运动时与休息时相比，健康肌肉中 [(11)C]醋酸盐摄取增加一致。术后 3 周短暂受损的肌肉功能在 3 个月时恢复。这些初步观察结果值得进一步研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46cb/3128267/b1b18aed6f01/11307_2010_415_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46cb/3128267/7c2295827269/11307_2010_415_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46cb/3128267/f8b1bd5ddb66/11307_2010_415_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46cb/3128267/b1b18aed6f01/11307_2010_415_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46cb/3128267/7c2295827269/11307_2010_415_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46cb/3128267/f8b1bd5ddb66/11307_2010_415_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46cb/3128267/b1b18aed6f01/11307_2010_415_Fig3_HTML.jpg

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