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成人铜绿假单胞菌菌血症:五例病例报告及文献复习。

Pseudomonas putida bacteremia in adult patients: five case reports and a review of the literature.

机构信息

Department of Infectious Diseases, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

出版信息

J Infect Chemother. 2011 Apr;17(2):278-82. doi: 10.1007/s10156-010-0114-0. Epub 2010 Sep 1.

Abstract

Pseudomonas putida belongs to the fluorescent group of Pseudomonas species, a group of opportunistic pathogens that primarily cause nosocomial infections. However, few cases of P. putida bacteremia in adult patients have been reported. We report five cases of P. putida bacteremia in adult patients and review 23 previously reported cases. Our five patients consisted of three cases of catheter-related bloodstream infection (CRBSI), one case of indwelling biliary drainage tube-related cholangitis, and one case of cholecystitis. Many of the 23 previously reported cases also included CRBSI. Of the clinical backgrounds, in all 28 reported cases including ours, 24 (85.7%) were immunocompromised. Of the clinical management, in CRBSI, devices were removed in almost all cases (92.9%). Antibiotic susceptibility data of our five cases and another previous case showed that patients with bacteremia had a high susceptibility of P. putida to anti-pseudomonal β-lactams. The prognosis for bacteremia with P. putida was good, as 26 (92.9%) of the total 28 cases were cured.

摘要

铜绿假单胞菌属于荧光假单胞菌群,这是一组机会致病菌,主要引起医院获得性感染。然而,成人中由铜绿假单胞菌引起的菌血症病例较少见。我们报告了五例成人铜绿假单胞菌菌血症病例,并回顾了 23 例先前报道的病例。我们的五例患者包括三例导管相关血流感染(CRBSI)、一例留置胆道引流管相关胆管炎和一例胆囊炎。在 23 例先前报道的病例中,许多也包括 CRBSI。在所有 28 例包括我们的病例在内的临床背景中,24 例(85.7%)为免疫功能低下。在 CRBSI 中,几乎所有病例(92.9%)都移除了设备。我们的五例病例和另一例先前病例的药敏数据显示,菌血症患者对假单胞菌属β-内酰胺类抗生素具有较高的敏感性。铜绿假单胞菌菌血症的预后良好,28 例总病例中有 26 例(92.9%)治愈。

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