Wildfeuer A, Laufen H, Haferkamp O
Department of Pathology, Faculty of Theoretical Medicine, University of Ulm/Donau, Fed. Rep. of Germany.
Arzneimittelforschung. 1990 Sep;40(9):1044-7.
3H-labelled fluconazole (CAS 86386-73-4) very rapidly penetrated into polymorphonuclear leucocytes (PMNLs) and macrophages (monocytes) isolated from volunteers. The concentration of the antimycotic in the PMNLs was about 28% and in the macrophages even 63% above that in the extracellular medium. At the concentrations examined (5, 10 and 20 micrograms/ml) fluconazole damaged cells of Candida albicans which had been phagocytized by PMNLs or macrophages. There is an evident synergism between therapeutically attainable concentrations of fluconazole and phagocytic cells and this militates against the intracellular survival of the fungus.
3H标记的氟康唑（CAS 86386-73-4）能非常迅速地渗透到从志愿者体内分离出的多形核白细胞（PMNLs）和巨噬细胞（单核细胞）中。抗真菌药在PMNLs中的浓度比细胞外培养基中的浓度高约28%，在巨噬细胞中的浓度甚至比细胞外培养基中的浓度高63%。在所检测的浓度（5、10和20微克/毫升）下，氟康唑会损伤被PMNLs或巨噬细胞吞噬的白色念珠菌细胞。氟康唑在治疗可达到的浓度与吞噬细胞之间存在明显的协同作用，这不利于真菌在细胞内存活。
