In-hospital mortality of disseminated tuberculosis in patients infected with the human immunodeficiency virus.

作者信息

dos Santos Rodrigo Pires, Deutschendorf Caroline, Scheid Karin, Goldani Luciano Zubaran

机构信息

Infectious Disease Service, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil.

出版信息

Clin Dev Immunol. 2011;2011. doi: 10.1155/2011/120278. Epub 2010 Aug 4.

DOI:10.1155/2011/120278

PMID:20811589

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2929489/

Abstract

BACKGROUND

Tuberculosis (TB) is a cause of significant morbidity and mortality in patients with AIDS. The goal of our study was to determine predictors of in-hospital mortality in patients with AIDS and disseminated tuberculosis in a middle-income country.

MATERIAL AND METHODS

We conducted a retrospective cohort study in a tertiary care center, for patients with AIDS in southern Brazil. From 1996 to 2008, all patients with the diagnosis of disseminated TB were included.

RESULTS

Eighty patients were included. In-hospital mortality was 35% (N = 28). On multivariate Cox regression analysis, low basal albumin (P < .01) was associated with death, and fever at admission was related to better survival (P < .01).

CONCLUSION

Albumin levels or fever are independent predictors of survival in patients with HIV and disseminated TB. They can serve as indirect markers of immunodeficiency in patients with disseminated TB and AIDS.

摘要