ICSH recommendations for the analysis of red cell, white cell and platelet size distribution curves. Methods for fitting a single reference distribution and assessing its goodness of fit. International Committee for Standardization in Haematology. ICSH Expert Panel on Cytometry.

The algorithm in Figure 7 summarizes the overall approach to fitting a single reference distribution. If no statistically significant difference is found, the investigation should assess whether the power of the chi-squared test was insufficient to detect differences of practical significance. If a statistical difference is found, Appendices B and C and Figure 6 may be used to determine whether the sample size and the power have led to the detection of an effect size too small to be of importance.