Centre for Transplantation and Renal Research, Westmead Millennium Institute at University of Sydney, Sydney, N.S.W., Australia.
Nephron Exp Nephrol. 2011;117(3):e47-52. doi: 10.1159/000320595. Epub 2010 Sep 1.
Based on new understanding of the diverse biological functions of macrophages and dendritic cells (DC), the focus of studies on these cells has been expanded from their pathogenic role in renal diseases to include their potential to regulate inflammation and restore renal architecture and function. By exploiting their regulatory function, macrophages or DC have been used to treat experimental renal disease following their adoptive transfer. This review summarizes current progress in the therapeutic use of macrophages and DC in renal diseases. Key issues for ongoing research are discussed.
基于对巨噬细胞和树突状细胞（DC）多种生物学功能的新认识，这些细胞的研究重点已从其在肾脏疾病中的致病作用扩展到包括它们调节炎症和恢复肾脏结构和功能的潜力。通过利用其调节功能，已经通过过继转移来治疗实验性肾脏疾病。本文总结了巨噬细胞和 DC 在肾脏疾病中的治疗应用的最新进展。讨论了正在进行的研究的关键问题。
