巨噬细胞在肾脏疾病中的致病和保护作用。
Pathogenic and protective role of macrophages in kidney disease.
机构信息
Centre for Transplantation and Renal Research, Westmead Millennium Institute, University of Sydney, Darcy Rd., Westmead, Sydney, NSW, Australia.
出版信息
Am J Physiol Renal Physiol. 2013 Jul 1;305(1):F3-11. doi: 10.1152/ajprenal.00122.2013. Epub 2013 May 1.
Abstract
Macrophages (MΦ) are located throughout kidney tissue, where they play important roles in homeostasis, surveillance, tolerance, and cytoprotection. MΦ are highly heterogeneous cells and exhibit distinct phenotypic and functional characteristics depending on their microenvironment and the disease type and stage. Recent studies have identified a dual role for MΦ in several murine models of kidney disease. In this review, we discuss the pathogenic and protective roles of the various MΦ subsets in experimental and human kidney diseases and summarize current progress toward the therapeutic use of MΦ in kidney diseases.
摘要
巨噬细胞（MΦ）分布于肾脏组织的各个部位，在维持内环境稳定、免疫监视、免疫耐受和细胞保护方面发挥着重要作用。MΦ是高度异质性的细胞，其表型和功能特征取决于其微环境以及疾病的类型和阶段。最近的研究在几种小鼠肾脏疾病模型中发现了 MΦ的双重作用。在这篇综述中，我们讨论了各种 MΦ亚群在实验性和人类肾脏疾病中的致病和保护作用，并总结了目前在肾脏疾病中利用 MΦ进行治疗的研究进展。
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