Onasanya Olukayode, Nochlin David, Casas Victor, Peddareddygari Leema Reddy, Grewal Raji P
Laboratory of Neurogenetics, New Jersey Neuroscience Institute, JFK Medical Center, 65 James Street, Edison NJ, 08820, USA.
Case Rep Med. 2010;2010. doi: 10.1155/2010/903252. Epub 2010 Aug 11.
Kikuchi-Fujimoto disease is a self-limited benign condition of unknown etiology characterized by cervical lymphadenopathy, fever, and leucopenia. An autoimmune hypothesis has been suggested and an association with systemic lupus erythematosus, Sjogren's disease, and antiphospholipid syndrome has been noted. We report a 27-year-old male who presented for evaluation of weakness and he was diagnosed with seropositive generalized myasthenia gravis and underwent a thymectomy. He was stable until five months post-thymectomy, when he developed a high fever associated with nontender cervical lymphadenopathy, chills, and night sweats. Histopathology of a cervical lymph gland biopsy was compatible with Kikuchi-Fujimoto lymphadenitis. He improved spontaneously and was asymptomatic at the followup six months later. Our case expands the association of Kikuchi-Fujimoto disease with autoimmune disorders to include myasthenia gravis.
菊池-藤本病是一种病因不明的自限性良性疾病，其特征为颈部淋巴结病、发热和白细胞减少。有人提出了自身免疫假说，并注意到它与系统性红斑狼疮、干燥综合征和抗磷脂综合征有关。我们报告一名27岁男性，因肌无力前来评估，被诊断为血清阳性全身型重症肌无力并接受了胸腺切除术。术后五个月前他病情稳定，但之后出现高热，伴有无痛性颈部淋巴结病、寒战和盗汗。颈部淋巴结活检的组织病理学与菊池-藤本淋巴结炎相符。他自行好转，六个月后的随访中无症状。我们的病例将菊池-藤本病与自身免疫性疾病的关联扩展至包括重症肌无力。
