Pace-Asciak Pia, Black Mindy Ann, Michel Rene P, Kost Karen
Department of Otolaryngology, Gordon and Leslie Diamond Health Care Centre, Vancouver, British Columbia.
J Otolaryngol Head Neck Surg. 2008 Dec;37(6):782-7.
Kikuchi-Fujimoto disease (KFD) is a rare, benign, self-limiting condition occasionally associated with systemic lupus erythematosus (SLE). Although rising in incidence, nonspecific symptoms make diagnosis difficult. We present a small case series and review the literature to increase awareness of this condition among otolaryngologists.
Nine cases of KFD were diagnosed between 2003 and 2006 at the McGill University Health Care institution by either excisional or fine-needle biopsy. Clinical and histologic features were reviewed in the context of a comprehensive analysis of the KFD literature.
Seven of nine cases are female, with a mean age of 27.2 years (range 18-35 years). Only one patient had systemic SLE predating KFD. Our results are comparable to those in the current literature regarding the association with SLE.
We present the first Canadian small case series and extensive review of the literature to highlight the clinical and pathologic features of this disease and its association with SLE.
菊池-藤本病（KFD）是一种罕见的、良性的、自限性疾病，偶尔与系统性红斑狼疮（SLE）相关。尽管其发病率在上升，但非特异性症状使得诊断困难。我们展示一个小病例系列并回顾文献，以提高耳鼻喉科医生对这种疾病的认识。
2003年至2006年间，在麦吉尔大学医疗保健机构通过切除活检或细针穿刺活检诊断出9例KFD。在对KFD文献进行全面分析的背景下，对临床和组织学特征进行了回顾。
9例中有7例为女性，平均年龄27.2岁（范围18 - 35岁）。只有1例患者在KFD之前患有系统性SLE。我们的结果与当前文献中关于与SLE关联的结果相当。
我们展示了首个加拿大小病例系列并对文献进行了广泛回顾，以突出这种疾病的临床和病理特征及其与SLE的关联。
