Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Cancer Causes Control. 2010 Dec;21(12):2173-81. doi: 10.1007/s10552-010-9637-z. Epub 2010 Sep 4.
To assess the association of recreational physical activity and anthropometric factors in relation to risk of ductal carcinoma in situ (DCIS) of the breast.
The association was examined in a cohort of 58,055 postmenopausal women participating in the Women's Health Initiative (WHI) clinical trials, among whom 450 cases of DCIS were ascertained after a median follow-up of 8.0 years. Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI).
After adjustment for covariates, the hazard ratio for DCIS among women with ≥ 20 metabolic equivalent task-hours per week (MET-h/week) of total recreational physical activity compared to women who did not engage in any recreational physical activity (0 MET-h/week) was 0.97 (95% CI 0.70-1.34). Neither body mass index nor waist circumference was associated with risk. In addition, physical activity and anthropometric factors were not associated with risk of either high-grade or low-/moderate-grade DCIS.
Recreational physical activity and anthropometric factors showed no association with risk of DCIS in postmenopausal women in the WHI clinical trial.
评估休闲体力活动与人体测量因素与乳腺导管原位癌 (DCIS) 风险的相关性。
在参加妇女健康倡议 (WHI) 临床试验的 58055 名绝经后妇女队列中研究了这种相关性，其中在中位数为 8.0 年的随访后确定了 450 例 DCIS 病例。使用 Cox 比例风险模型估计风险比 (HR) 和 95%置信区间 (95%CI)。
在调整了协变量后，每周进行≥20 个代谢当量任务小时（MET-h/周）的总休闲体力活动的女性与不进行任何休闲体力活动的女性相比（0 MET-h/周），患 DCIS 的风险比为 0.97（95%CI 0.70-1.34）。体重指数和腰围均与风险无关。此外，体力活动和人体测量因素与高级或低/中等级 DCIS 的风险均无关联。
在 WHI 临床试验中，绝经后妇女的休闲体力活动和人体测量因素与 DCIS 风险无关联。
