Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of the Ministry of Education, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, Hubei, People's Republic of China.
J Nat Med. 2011 Jan;65(1):50-6. doi: 10.1007/s11418-010-0456-z. Epub 2010 Sep 3.
Ginkgo biloba, an herbal medication, is capable of lowering glucose, fat, and lipid peroxide in diabetic patients. In the current study, we tested the hypothesis that Ginkgo biloba extract (GBE) prevented hyperinsulinism-induced glucose intolerance in hepatocytes. We investigated the effects of GBE on glucose consumption, glucokinase activity, and mRNA levels of key genes in glucose metabolism and the insulin signaling pathway. To better show its efficacy, we included a control group that was treated with rosiglitazone, a type of thiazolidinedione (TZD). The data indicated that GBE repressed glucose uptake under normal conditions, while it dramatically improved glucose tolerance under insulin-resistant conditions. Furthermore, after analyzing gene expression, we suggest that GBE chiefly exerts its effects by stimulating IRS-2 transcription. It should be noted that, unlike rosiglitazone, GBE did not stimulate excessive glucose uptake as it improved glucose tolerance. It is said that GBE treatment could avoid drug-induced obesity. Our data suggest that GBE has the potential to prevent insulin resistance and is a promising anti-diabetic drug.
银杏叶，一种草药，能够降低糖尿病患者的血糖、脂肪和脂质过氧化物。在本研究中，我们检验了银杏叶提取物（GBE）是否可以预防高胰岛素血症诱导的肝细胞葡萄糖不耐受的假说。我们研究了 GBE 对葡萄糖消耗、葡糖激酶活性以及葡萄糖代谢和胰岛素信号通路关键基因的 mRNA 水平的影响。为了更好地显示其疗效，我们还包括了用罗格列酮（一种噻唑烷二酮类药物）治疗的对照组。数据表明，GBE 在正常情况下抑制葡萄糖摄取，而在胰岛素抵抗情况下则显著改善葡萄糖耐量。此外，在分析基因表达后，我们认为 GBE 主要通过刺激 IRS-2 转录发挥作用。值得注意的是，与罗格列酮不同，GBE 在改善葡萄糖耐量的同时并没有刺激过度的葡萄糖摄取。据说 GBE 治疗可以避免药物引起的肥胖。我们的数据表明，GBE 具有预防胰岛素抵抗的潜力，是一种有前途的抗糖尿病药物。
