Ferlazzo Guido, Münz Christian
Laboratory of Immunology and Biotherapy, Department of Human Pathology, School of Medicine, University of Messina, Policlinico, Via Consolare Valeria, 98125 Messina, Italy.
J Clin Immunol. 2009 May;29(3):265-73. doi: 10.1007/s10875-009-9283-y. Epub 2009 Mar 12.
In recent years, it has been realized that innate lymphocytes do not act in isolation but potentiate their efficiency by interacting with each other, resulting even in the regulation of adaptive immune response. One such cross-talk exists between dendritic cells (DCs) and natural killer (NK) cells. Here, we summarize recent studies on which subsets of these two innate immune components participate in this interaction, how it influences immune responses, and to which extent similar stimuli are integrated by DCs and NK cells during innate immunity.
We suggest that this cross-talk should be harnessed by activating both of these innate leucocyte populations with new adjuvant formulations for immunotherapies.
近年来，人们已经认识到固有淋巴细胞并非单独发挥作用，而是通过相互作用来增强其效能，甚至对适应性免疫反应进行调节。树突状细胞（DC）和自然杀伤（NK）细胞之间就存在这样一种相互作用。在此，我们总结了近期关于这两种固有免疫成分的哪些亚群参与这种相互作用、其如何影响免疫反应以及在固有免疫过程中DC和NK细胞在多大程度上整合相似刺激的研究。
我们建议，应通过使用新的佐剂配方激活这两种固有白细胞群体来利用这种相互作用，以用于免疫治疗。
