Department of Aquatic Biomedical Sciences, School of Marine Biomedical Sciences, College of Ocean Sciences & Marine and Environmental Research Institute, Jeju National University, Jeju, South Korea.
Fish Shellfish Immunol. 2010 Dec;29(6):1037-43. doi: 10.1016/j.fsi.2010.08.017. Epub 2010 Sep 9.
The effect of Lactobacillus sakei BK19 (10(8) cells g(-1)) supplemented diet fed to kelp grouper, Epinephelus bruneus against streptococcosis caused by Streptococcus iniae and Streptococcus parauberis with reference to the innate immune response and disease resistance was evaluated at 1, 2, and 4 weeks. Maximum reduction in mortalities was observed in kelper feeding the probiotic diet for two weeks after challenged with the pathogens when compared to the infected group fed with basal diet; similarly the cellular and humoral immune responses such as head kidney macrophage phagocytic and peroxidase activities, serum lysozyme activity, and total protein levels increased significantly. The results reveal that, in streptococcosis infected kelp grouper feeding L. sakei BK19 enriched diet affords a higher level of disease protection due to stimulation of immune system.
将 10(8) 个细胞/克的清酒乳杆菌 BK19 补充饮食喂养到真鲷（Epinephelus bruneus）中，以评估其对由鳗弧菌（Streptococcus iniae）和副溶血弧菌（Streptococcus parauberis）引起的链球菌病的影响，并参考先天免疫反应和抗病能力，分别在 1、2 和 4 周进行评估。与感染组相比，在受到病原体攻击后，连续两周食用益生菌饮食的真鲷死亡率最高；同样，头肾巨噬细胞吞噬和过氧化物酶活性、血清溶菌酶活性和总蛋白水平等细胞和体液免疫反应也显著增加。结果表明，在链球菌病感染的真鲷中，由于免疫系统的刺激，食用富含清酒乳杆菌 BK19 的饮食可提供更高水平的疾病保护。
