Department of Gastroenterology, Shanghai Xinhua Hospital, Center for Clinical Epidemiology, Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
Prev Med. 2010 Nov;51(5):412-5. doi: 10.1016/j.ypmed.2010.08.013. Epub 2010 Sep 15.
To determine the prevalence of and risk factors for dyslipidemia in Shanghai.
A cross-sectional survey of 14,385 subjects (6150 men) with mean age of 49.5 (14.5) years was conducted between October 2002 and April 2003 using randomized, stratified cluster sampling. Serum triglyceride, total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C) were measured.
Dyslipidemia, as defined by NCEP ATP III criteria, occurred in 5255 subjects (36.5%). The prevalences of mixed hyperlipidemia (elevated TC and triglycerides), isolated hypertriglyceridemia, isolated hypercholesterolemia and isolated low HDL-C were 3.8%, 24.9%, 3.2% and 4.7%, respectively. The prevalence of dyslipidemia increased with age, with the peak prevalence (43%) occurring after age 55. Dyslipidemia was more common in males than females (40.2% vs. 33.8%) and in rural than urban populations (44.2% vs. 32.3%). Serum triglyceride and TC increased with body mass index (BMI) and waist circumference. Mean serum triglyceride concentrations in males and rural residents were higher than those in females and urban residents, respectively, whereas the reverse was true for HDL-C values. Multivariate analysis revealed that dyslipidemia was associated with age, gender, area of residence, BMI and waist circumference.
There is a high prevalence of dyslipidemia, mainly hypertriglyceridemia and low HDL-C, in Shanghai.
确定上海地区血脂异常的流行情况及其危险因素。
2002 年 10 月至 2003 年 4 月期间，采用随机、分层聚类抽样的方法，对 14385 名（6150 名男性）平均年龄为 49.5（14.5）岁的受试者进行了一项横断面调查。检测血清甘油三酯、总胆固醇（TC）和高密度脂蛋白胆固醇（HDL-C）。
根据 NCEP ATP III 标准，5255 名（36.5%）受试者患有血脂异常。混合性高脂血症（TC 和甘油三酯升高）、单纯性高甘油三酯血症、单纯性高胆固醇血症和单纯性低 HDL-C 的患病率分别为 3.8%、24.9%、3.2%和 4.7%。血脂异常的患病率随年龄增长而增加，55 岁以后达到峰值（43%）。血脂异常在男性中比女性更常见（40.2%比 33.8%），在农村地区比城市地区更常见（44.2%比 32.3%）。血清甘油三酯和 TC 随体重指数（BMI）和腰围增加而升高。男性和农村居民的血清甘油三酯平均浓度高于女性和城市居民，而 HDL-C 值则相反。多变量分析显示，血脂异常与年龄、性别、居住地区、BMI 和腰围有关。
上海地区血脂异常患病率较高，主要为高甘油三酯血症和低 HDL-C。
