Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Yongin-si, Gyeonggi-do 446-701, Republic of Korea.
J Ethnopharmacol. 2010 Nov 11;132(2):529-32. doi: 10.1016/j.jep.2010.08.049. Epub 2010 Sep 15.
The present study aimed to investigate the effects of Scutellariae radix (SR) and Aloe vera gel (AV), alone or in combination, on levels of immunoglobulin E (IgE) and inflammatory cytokines in spontaneous atopic dermatitis(AD)-like skin lesions.
After spontaneous AD-like skin lesion was developed by adaptation to conventional conditions, mice were randomly assigned to control, SR (50 mg/kg, p.o.), AV (0.8 mg/kg, p.o.) and SRAV (50 mg of SR and 0.8 mg of AV/kg, p.o.) groups, and were treated for 6 weeks.
SR and SRAV suppressed IL-5 levels compared with control, but had no effects on IgE levels (P<0.05). AV increased IgE levels, but decreased both IL-5 and IL-10 compared with control (P<0.05).
These results suggest that SR and AV modulate immunological responses in AD, mainly through influencing IL-5 or IL-10 levels.
本研究旨在探讨黄芩（SR）和芦荟凝胶（AV）单独或联合应用对特应性皮炎（AD）样皮肤损伤中免疫球蛋白 E（IgE）和炎症细胞因子水平的影响。
通过适应常规条件诱导自发性 AD 样皮肤损伤后，将小鼠随机分为对照组、SR（50mg/kg，po）组、AV（0.8mg/kg，po）组和 SRAV（50mg SR 和 0.8mg AV/kg，po）组，并治疗 6 周。
与对照组相比，SR 和 SRAV 抑制了 IL-5 水平，但对 IgE 水平没有影响（P<0.05）。AV 增加了 IgE 水平，但与对照组相比，IL-5 和 IL-10 水平降低（P<0.05）。
这些结果表明，SR 和 AV 通过影响 IL-5 或 IL-10 水平调节 AD 中的免疫反应。
