平面细胞极性信号转导、纤毛和极化纤毛摆动。
Planar cell polarity signaling, cilia and polarized ciliary beating.
机构信息
Howard Hughes Medical Institute, Section of Molecular Cell and Developmental Biology & Institute for Cellular and Molecular Biology, University of Texas at Austin, 1 University Station C1000, TX 78712, USA.
出版信息
Curr Opin Cell Biol. 2010 Oct;22(5):597-604. doi: 10.1016/j.ceb.2010.07.011.
Abstract
Planar cell polarity signaling governs a wide array of polarized cell behaviors in animals. Recent reports now show that PCP signaling is essential for the directional beating of motile cilia. Interestingly, PCP signaling acts in a variety of ciliated cell types that use motile cilia to generate directional fluid flow in very different ways. This review will synthesize these recent papers and place them in context with previous studies of PCP signaling in polarized cellular morphogenesis and collective cell movement.
摘要
平面细胞极性信号转导控制着动物中广泛的极化细胞行为。最近的报告显示，PCP 信号对于运动纤毛的定向摆动是必不可少的。有趣的是，PCP 信号在多种纤毛细胞类型中发挥作用，这些细胞类型通过运动纤毛以非常不同的方式产生定向的流体流动。这篇综述将综合这些最新的论文，并将它们置于 PCP 信号在极化细胞形态发生和细胞集体运动中的先前研究背景下。
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本文引用的文献
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Planar cell polarity breaks bilateral symmetry by controlling ciliary positioning.平面细胞极性通过控制纤毛定位打破了双边对称性。
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Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus.钙黏蛋白 Celsr2 和 Celsr3 的缺失会损害室管膜纤毛的发生，导致致命性脑积水。
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Vangl2 directs the posterior tilting and asymmetric localization of motile primary cilia.Vangl2 指导运动性初级纤毛的向后倾斜和不对称定位。
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Cilia organize ependymal planar polarity.纤毛组织室管膜平面极性。
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Planar cell polarity enables posterior localization of nodal cilia and left-right axis determination during mouse and Xenopus embryogenesis.平面细胞极性在小鼠和非洲爪蟾胚胎发生过程中使 nodal 纤毛的后向定位和左右轴的确定成为可能。
PLoS One. 2010 Feb 2;5(2):e8999. doi: 10.1371/journal.pone.0008999.
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Dev Biol. 2010 Mar 15;339(2):418-28. doi: 10.1016/j.ydbio.2010.01.003. Epub 2010 Jan 11.
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Secreted frizzled-related protein disrupts PCP in eye lens fiber cells that have polarised primary cilia.分泌卷曲相关蛋白扰乱了具有极化初级纤毛的眼晶状体纤维细胞中的 PCP。
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