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Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus.
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Coupling between hydrodynamic forces and planar cell polarity orients mammalian motile cilia.
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Vangl2 directs the posterior tilting and asymmetric localization of motile primary cilia.
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Cilia organize ependymal planar polarity.
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Planar cell polarity enables posterior localization of nodal cilia and left-right axis determination during mouse and Xenopus embryogenesis.
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Planar polarization of node cells determines the rotational axis of node cilia.
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PCP effector gene Inturned is an important regulator of cilia formation and embryonic development in mammals.
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Planar cell polarity effector gene Fuzzy regulates cilia formation and Hedgehog signal transduction in mouse.
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