虽然这听起来可能有些奇怪：Wnt 信号、平面细胞极性和纤毛之间存在着许多联系。
Strange as it may seem: the many links between Wnt signaling, planar cell polarity, and cilia.
机构信息
Howard Hughes Medical Institute, Section of Molecular Cell and Developmental Biology, Institute for Cellular and Molecular Biology, University of Texas, Austin, TX 78712, USA.
出版信息
Genes Dev. 2011 Feb 1;25(3):201-13. doi: 10.1101/gad.2008011.
Abstract
Cilia are important cellular structures that have been implicated in a variety of signaling cascades. In this review, we discuss the current evidence for and against a link between cilia and both the canonical Wnt/β-catenin pathway and the noncanonical Wnt/planar cell polarity (PCP) pathway. Furthermore, we address the evidence implicating a role for PCP components in ciliogenesis. Given the lack of consensus in the field, we use new data on the control of ciliary protein localization as a basis for proposing new models by which cell type-specific regulation of ciliary components via differential transport, regulated entry and exit, or diffusion barriers might generate context-dependent functions for cilia.
摘要
纤毛是重要的细胞结构，它们与多种信号级联反应有关。在这篇综述中，我们讨论了纤毛与经典 Wnt/β-连环蛋白途径和非经典 Wnt/平面细胞极性（PCP）途径之间存在联系的现有证据。此外，我们还讨论了 PCP 成分在纤毛发生中的作用的证据。鉴于该领域缺乏共识，我们使用有关纤毛蛋白定位控制的新数据作为提出新模型的基础，通过该模型，通过差异运输、调节进入和退出或扩散障碍对纤毛组件进行细胞类型特异性调节，可能为纤毛产生依赖于上下文的功能。
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