Howard Hughes Medical Institute, Section of Molecular Cell and Developmental Biology, Institute for Cellular and Molecular Biology, University of Texas, Austin, TX 78712, USA.
Genes Dev. 2011 Feb 1;25(3):201-13. doi: 10.1101/gad.2008011.
Cilia are important cellular structures that have been implicated in a variety of signaling cascades. In this review, we discuss the current evidence for and against a link between cilia and both the canonical Wnt/β-catenin pathway and the noncanonical Wnt/planar cell polarity (PCP) pathway. Furthermore, we address the evidence implicating a role for PCP components in ciliogenesis. Given the lack of consensus in the field, we use new data on the control of ciliary protein localization as a basis for proposing new models by which cell type-specific regulation of ciliary components via differential transport, regulated entry and exit, or diffusion barriers might generate context-dependent functions for cilia.
纤毛是重要的细胞结构，它们与多种信号级联反应有关。在这篇综述中，我们讨论了纤毛与经典 Wnt/β-连环蛋白途径和非经典 Wnt/平面细胞极性（PCP）途径之间存在联系的现有证据。此外，我们还讨论了 PCP 成分在纤毛发生中的作用的证据。鉴于该领域缺乏共识，我们使用有关纤毛蛋白定位控制的新数据作为提出新模型的基础，通过该模型，通过差异运输、调节进入和退出或扩散障碍对纤毛组件进行细胞类型特异性调节，可能为纤毛产生依赖于上下文的功能。
